Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...

Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a ...

Researchers have devised a molecular structural modification that boosts the efficacy of antisense oligonucleotide-based drugs by replacing the RNA strand of a heteroduplex oligonucleotide with DNA.

Antisense oligonucleotides (ASO) hold great promise for pharmacotherapy. Now, researchers at Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, advancing their earlier work on a ...

Although the concept of using synthetic oligonucleotides to modulate RNA function was described as early as 1978, 1 its realization in the form of drugs approved by the Food and Drug Administration ...

Adenine was first discovered in 1885 by the German physiologist Albrecht Kossel. He isolated adenine from the pancreas of oxen and named it "adenine" derived from the Greek word "aden," meaning gland.

Gene therapy has been heralded as the new frontier of medicine, but there are still many limitations to current technologies; among them, how to deliver therapeutic genes to specific cells, and only ...

While sifting through the juvenile mammoth’s genetic materials for traces of RNA, the team made another surprising discovery: ...