Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...

Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a ...

Researchers have devised a molecular structural modification that boosts the efficacy of antisense oligonucleotide-based drugs by replacing the RNA strand of a heteroduplex oligonucleotide with DNA.

Thought LeadersEbbe Sloth Andersen, Ph.D.Associate Professor, iNANOAarhus University In this interview, AZoNano speaks with Associate Professor Ebbe Sloth Andersen from Aarhus University about a new ...

Antisense oligonucleotides (ASO) hold great promise for pharmacotherapy. Now, researchers at Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, advancing their earlier work on a ...

Antisense oligonucleotides (ASOs) are small, single-stranded molecules that can suppress the expression of targeted genes and thereby achieve therapeutic effects. However, many ASO-based drug ...

While sifting through the juvenile mammoth’s genetic materials for traces of RNA, the team made another surprising discovery: ...

Gene therapy has been heralded as the new frontier of medicine, but there are still many limitations to current technologies; among them, how to deliver therapeutic genes to specific cells, and only ...