The shikimate pathway is fundamental for the biosynthesis of aromatic amino acids—tryptophan, tyrosine and phenylalanine—in plants, bacteria and fungi. This pathway, which is absent in mammals, has ...

Haemoglobin is a paradigm for exploring allosteric regulation, wherein ligand binding at one site induces conformational changes that affect functional activity at a distant site. These structural ...

Sir2, an enzyme belonging to sirtuins, has been shown to be involved in the deacetylation of proteins. Researchers from the ...

Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation ...