Expanded repetitive sequences are infamous for causing inherited disease. Think poly-Q tracts that cause Huntington’s or the C9orf72 hexanucleotide run-ons that trigger ALS/FTD. However, given people ...
A mutator phenotype is well documented in tumours of patients with hereditary non-polyposis colorectal cancer (HNPCC), and also in a subset of sporadic cancers (Aaltonen et al., 1993). Such genomic ...
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