Most current approaches rely on adding nuclear localization signal (NLS) motifs to the ends of Cas9 to facilitate nuclear entry. However, this method is inefficient, and much of the Cas9 that is ...

The Nature Index 2024 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...

Unnaturally repeating copies of genetic code called tandem duplications within the UBTF gene lead to a high-risk form of ...

While CRISPR-mediated gene editing has led to powerful advances across biology, medicine, and agriculture, challenges persist in optimizing the editing efficiency of enzymes, such as the widely used ...

The centrosome serves as the microtubule-organizing center and plays a critical role in cell division. Centrosomal RNAs (cnRNAs) have been reported to enable precise spatiotemporal control of gene ...