L-type Ca²⁺ currents determine the shape of cardiac action potentials (AP) and the magnitude of the myoplasmic Ca²⁺ signal, which regulates the contraction force. The auxiliary Ca²⁺ channel subunits ...

The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...

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Instead, CICR acts as a dormant but dangerous silent risk factor, staying quiet under normal conditions yet becoming a major driver of pathology when RyR1 signaling is disrupted. This model resolves a ...

Real-time imaging of sub-cellular reactive oxygen species, Ca2+ signaling, and excitation-contraction coupling in skeletal muscle under physiological and pathophysiological conditions. The research in ...

Cardiac muscle tissue, or myocardium, is a type of muscle tissue that forms the heart. It contracts and releases involuntarily and keeps the heart pumping blood around the body. The human body ...

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...